Preparation of Ti-based metal organic framework/chitosan scaffold loaded with adriamycin and its application in bone regeneration and antitumor

• 1、School of biomedical and pharmaceutical sciences, Guangdong University of Technology, Guangzhou 510006

Abstract：Surgical resection is the main treatment modality for bone tumors; however, it causes local bone defects and predisposes to tumor recurrence. Therefore, biomaterials that combine both treatment and repair are urgently needed after bone tumor surgery. In this study, we propose to synthesize Ti-MOF with ultra-high specific surface area, and then Ti-MOF loaded with adriamycin (DOX), mixed with chitosan solution and lyophilized to form scaffolds. The osteogenic differentiation-promoting properties of Ti-MOF, the drug loading of Ti-MOF, the anti-tumor activity of DOX@Ti-MOF and its structural changes of the scaffold after implantation into the scaffold material were investigated. The results showed that Ti-MOF had a high specific surface area of 1116 cm3/g and excellent biocompatibility and ability to promote bone differentiation; the drug loading of Ti-MOF was DOX/Ti-MOF: 6.83 mg/g; and DOX@Ti-MOF has excellent anti-tumor activity. SEM results showed that the addition of DOX@Ti-MOF had no significant effect on the scaffold structure. Based on the good osteogenic differentiation-promoting ability and anti-tumor activity of DOX@Ti-MOF, it makes DOX@Ti-MOF/CS may be a promising platform for postoperative bone tumor removal and bone defect repair.

Keywords： Ti-MOF DOX Chitosan bone tumor